Her work explores stories about land, mythology, ritual, thresholds and imprints, the individual's relationship to landscape, and a land’s ability to evoke memory whether real or imagined. Photography is her primary medium however drawings, found images, printmaking, video, and writing are also incorporated into her practice. Much of her inspiration is grounded in literature.
Her first book, a collection of photographs and drawings made in Iceland between 2011-2013 entitled 'As if it should have been a quarry' was released in late 2013 with Damiani publishers and includes an introductory essay by Eduardo Cadava. As if it should have been a quarry was recently shown as a solo exhibition at La Galerie Particulière in Paris and Brussels. Most recently this work was featured as part of a group exhibition entitled "Fragments" at La Frontiera gallery in Paris.
Mirlesse's work has been the subject of features in The British Journal of Photography, Time Magazine's Lightbox, Interview Magazine, The New Yorker, and Le Monde's M magazine. She was nominated three times for World Press Photo's annual Joop Swart Masterclass (2009, 2011, 2012) and was chosen as a notable emerging photographer of 2013 by The Magenta Foundation. Mirlesse has contributed commissioned works to The New York Times, T Magazine, Le Monde, M, Le Figaro, The Wall Street Journal, and Vogue Italia, among other publications.
Additionally, Mirlesse has contributed as a writer to The Paris Review, BOMB Magazine, Aperture, Art in America, FOAM magazine, and the Pompidou Center's Les Cahiers quarterly journal collecting more than twenty five interviews with various artists and curators as part of an ongoing conversations series.
She is part of the faculty at Paris College of Art, a visiting lecturer at Parsons Paris, and has been invited to participate in the conference programming at the Centre Pompidou.
In June of 2017 she completed an artist residency at Villa Lena Foundation in Italy and has been invited to participate in another at Santa Fe Arts Institute in New Mexico during their 2018 session.