Her work explores stories about land, geology, ritual, thresholds and imprints, the individual's relationship to origin, and a place’s ability to evoke narrative whether real or imagined. Much of her inspiration is grounded in literature. Photography is her primary medium however drawings, found images, relief prints, stone work, video, and writing are also incorporated into her practice.
Her first book, a collection of photographs and drawings made in Iceland between 2011-2013 entitled 'As if it should have been a quarry' was released in late 2013 with Damiani publishers and includes an introductory essay by Eduardo Cadava. As if it should have been a quarry was shown as a solo exhibition at La Galerie Particulière in Paris and Brussels. More recently this work was featured as part of a group exhibition entitled "Fragments" at La Frontiera gallery in Paris.
Mirlesse's work has been the subject of features in The British Journal of Photography, Time Magazine's Lightbox, BOMB, Interview Magazine, The New Yorker, and Le Monde's M magazine. She was nominated three times for World Press Photo's annual Joop Swart Masterclass (2009, 2011, 2012) and was chosen as a notable emerging photographer of 2013 by The Magenta Foundation. Mirlesse has contributed commissioned works to The New York Times, T Magazine, Le Monde, M, Le Figaro, The Wall Street Journal, and Vogue Italia, among other publications.
Additionally, Mirlesse has contributed as a writer to The Paris Review, BOMB Magazine, Aperture, Art in America, FOAM, Frieze and the Centre Pompidou’s Les Cahiers du MNAM quarterly journal collecting more than twenty five interviews over the last decade with various artists and curators as part of an ongoing conversations series.
She is a visiting lecturer at Parsons Paris, gives courses at Paris College of Art, and has been invited to both speak at and organize the conference programming at the Centre Pompidou.
In 2018 she was an artist-in-residence at Santa Fe Art Institute in New Mexico.
Mirlesse’s second monograph, Pietra di Luce, will be published with Les Graphiquants in 2019 and includes essays by Federica Soletta and Jean-Pierre Criqui.